This page contains Resident Evil 5 Hints for Playstation 3 called "Defeating Wesker" and has been posted or updated on Mar 7, 2010 by Cobyman. Let us know what you think of this Hint by thumbs voting.
Use the following trick to defeating Wesker's final form. Once you have saved Sheva from Wesker and have pushed the boulder over to allow her to join you, you will once again be attacked by Wesker, when you run to the higher ground where you faced him earlier. Like before, dodge his attacks as you shoot his heart, which alternates between his chest and back. Once you do enough damage to his heart, he will kneel down and push his arm into the ground. It then comes up around him as many swirling tentacles, protecting him from fire. If you wait and do nothing after he gets back up, you will see a cinematic of tentacles recovering his heart, which you do not want to happen. To prevent this, as soon after the swirling tentacles recede, run up to him and there should be a button event will begin, allowing you to hold him while Sheva stabs him (and later you), which is how you can finally kill him.
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