This page contains BioShock 2 Hints for Xbox 360 called "Defeating Big Sisters" and has been posted or updated on Mar 11, 2010 by next0106. Let us know what you think of this Hint by thumbs voting.
Defeating Big Sisters
Before you fight the second Big Sister (if you are harvesting ADAM but saving the girls), you will get an Enrage Plasmid. There are two bodies to scrounge ADAM from. One is more easily securable, which has a security camera, a rocket launcher bot, and a large puddle of water in this area. The Big Daddy comes back multiple times. If you drop off the little girl in her hole near here, you can wait for the Big Sister to show up. Then, enrage the Big Daddy so that he will take on and kill the Big Sister. Your only concern will be Splicers and the Big Daddy after he is done with the Big Sister.
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