| Unlockable: | How to Unlock: |
| Ammo Inventor | The player has successfully invented all possible ammo types. |
| Avid Inventor | Successfully invent at least 100 items. |
| Basic Inventor | The player has successfully invented at least one item. |
| Bought One Slot | The player has purchased one slot in any Plasmid or Tonic track. |
| Dealt with every Little Sister | The player has either Harvested or Rescued every possible Little Sister. |
| Five Fully Upgraded Weapons | Fully upgrade five weapons. |
| Four Fully Upgraded Weapons | Fully upgrade four weapons. |
| Fully Researched Bouncer | Fully research the Bouncer. |
| Fully Researched Gun Splicer | The player has fully researched the Leadhead Splicer. |
| Fully Researched Houdini Splicer | Fully research the Houdini Splicer. |
| Fully Researched Little Sister | Fully research the Little Sister. |
| Fully Researched Nitro Slicer | Fully research the Nitro Splicer. |
| Fully Researched Rosie | Fully research the Rosie. |
| Fully Researched Spider Splicer | The player has fully researched the Spider Splicer. |
| Fully Researched Thug Splicer | The player has fully researched the Thuggish Splicer. |
| Hacked a Safe | The player has successfully hacked a safe. |
| Hacked a Security Bot | The player has successfully hacked a security bot. |
| Hacked a Security Camera | The player has successfully hacked a security camera. |
| Hacked a Turret | The player has successfully hacked a turret. |
| Hacked a Vending Machine | The player has successfully hacked a vending machine. |
| Lucky Winner | Hit the jackpot at a slot machine. |
| Maxed All Tracks | Purchased every slot in all four Plasmid and Tonic tracks. |
| Maxed One Track | The player has purchased every slot in one of the Plasmid or Tonic tracks. |
| One Fully Upgraded Weapon | The player has fully upgraded one weapon. |
| One Successful Hack | The player has performed at least one successful hack. |
| Prolific Photographer | Take at least one photo in every research group. |
| Quality Research Photo | The player has taken a Research Photo of the highest grade. |
| Research PhD | Max out all possible research. |
| Researched a Splicer | The player has taken at least one Research Photo of a Splicer. |
| Seriously Good at This | The player has completed the game on the Hard difficulty setting. |
| Skilled Hacker | The player has successfully completed 50 hacks. |
| Three Fully Upgraded Weapons | The player has fully upgraded three weapons. |
| Toaster in the Tub | The player has shocked an enemy in the water. |
| Tonic Collector | Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks. |
| Two Fully Upgraded Weapons | The player has fully upgraded two weapons. |
| Upgraded a Weapon | The player has acquired at least one weapon upgrade. |
| Weapon Specialist | Acquire all upgrades for all weapons. |
| Unlockable: | How to Unlock: |
| Became a Big Daddy (Bronze) | The player has become a Big Daddy. |
| Broke Fontain's Mind Control (Bronze) | The player has broken Fontaine's mind control. |
| Completed Cohen's Masterpiece (Bronze) | The player has completed Sander Cohen's great masterpiece. |
| Completed Welcome (Bronze) | The player has successfully completed the Welcome To Rapture Level. |
| Defeated Andrew Ryan (Bronze) | The player has defeated Andrew Ryan. |
| Defeated Atlas (Bronze) | The player has defeated Atlas. |
| Defeated Dr. Steinman (Bronze) | The player has defeated the crazed Dr. Steinman. |
| Defeated Peach Wilkins (Bronze) | The player has defeated Peach Wilkins. |
| Found Cohen's Room (Bronze) | The player has entered Sander Cohen's personal quarters. |
| Irony (Bronze) | The player has taken a picture of Sander Cohen's corpse. |
| Little Sister Savior (Bronze) | The player has completed the game without harvesting any Little Sisters. |
| Restored the Forest (Bronze) | The player has restored the forests of Arcadia. |
| Unlockable: | How to Unlock: |
| "A Shocking Turn of Events"- Collector | Found all collectable Roses in "A Shocking Turn of Events". |
| "A Shocking Turn of Events"- Expert | Rescued the Little Sister in "A Shocking Turn of Events" in under 4:00. |
| "A Shocking Turn of Events"- Master Electrician | Charged up the Ferris Wheel 9 different times in "A Shocking Turn of Events". |
| "A Shocking Turn of Events"- Rescuer | Rescued the Little Sister in "A Shocking Turn of Events". |
| "The 'I' in Team"- Collector | Found all collectable Roses in "The 'I' in Team". |
| "The 'I' in Team"- Expert | Rescued the Little Sister in "The 'I' in Team" in under 3:00. |
| "The 'I' in Team"- Pacifist | Rescued the Little Sister in "The 'I' in Team" without destroying any Machine Gun Turrets. |
| "The 'I' in Team"- Rescuer | Rescued the Little Sister in "The 'I' in Team". |
| "Worlds of Hurt"- Collector | Found all collectable Roses in "Worlds of Hurt". |
| "Worlds of Hurt"- Expert | Rescued the Little Sister in "Worlds of Hurt in under 15:00, on medium or higher difficulty. |
| "Worlds of Hurt"- Rescuer | Rescued the Little Sister in "Worlds of Hurt". |
| "Worlds of Hurt"- Tough Guy | Rescued the Little Sister in "Worlds of Hurt" using only plasmids, tonics, the wrench, and the research camera, on medium or higher difficulty. |
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