| Unlockable: | How to Unlock: |
| 10 Blocks (20 GP) | Record 10 blocks or more with any team. |
| 10 Online Ranked Wins (25 GP) | Win 10 online ranked games. |
| 15 Steals (20 GP) | Record 15 steals or more with any team. |
| 15 Threes (15 GP) | Make 15 three pointers or more with any team. |
| 20 Online Ranked Wins (30 GP) | Win 20 online ranked games. |
| 2K Beats Playlist (10 GP) | Create a 2K Beats playlist. |
| 3 Online Ranked Streak (15 GP) | Win 3 online ranked games in a row. |
| 3-For-All (20 GP) | Make at least 10 3pt FG's while shooting at least 45% from 3pt range with any team. |
| 30 Assists (20 GP) | Record 30 assists or more with any team. |
| 3pt Shootout (15 GP) | Win the 3pt Shootout. |
| 5 Online Ranked Streak (20 GP) | Win 5 online ranked games in a row. |
| 5 Online Ranked Wins (15 GP) | Win 5 online ranked games. |
| All-Heart (15 GP) | Start the 4th period losing by 10 or more points and win the game with any team. |
| All-Hustle (15 GP) | Record at least 10 offensive rebounds, 5 blocks and 5 steals with any team. |
| Allen Iverson (25 GP) | Record at least 30 points, 8 assists and 3 steals with Allen Iverson. |
| Better to Give (20 GP) | Share any file type through 2K Share. |
| Carmelo Anthony (25 GP) | Record at least 40 points and 8 rebounds with Carmelo Anthony. |
| Cavaliers vs. Wizards (15 GP) | User controlled team must win this matchup on All-Star difficulty. |
| Celtics vs. Lakers (15 GP) | User controlled team must win this matchup on All-Star difficulty. |
| Chris Bosh (25 GP) | Record at least 30 points, 10 rebounds and 2 blocks with Chris Bosh. |
| Chris Paul (25 GP) | Record at least 20 points, 10 assists and 3 steals with Chris Paul. |
| Create Player (10 GP) | Use the Create Player feature. |
| Defensive FG% (15 GP) | Hold the opposing team's FG% below 40% with any team. |
| Dunk-Off (35 GP) | Defeat any challenger in a Dunk-Off. |
| Dwight Howard (25 GP) | Record at least 20 points, 15 rebounds and 3 blocks with Dwight Howard. |
| Dwyane Wade (25 GP) | Record at least 26 points, 5 rebounds and 7 assists with Dwyane Wade. |
| East vs. West (15 GP) | User controlled team must win this matchup on All-Star difficulty. |
| Gilbert Arenas (25 GP) | Record at least 35 points, 3 steals and 5 threes with Gilbert Arenas. |
| Good Hands (20 GP) | Record 20 assists with no more than 5 turnovers with any team. |
| Good Teammate (20 GP) | Earn a positive "teammate rating" in the online Team-Up Mode. |
| Ice Water (15 GP) | FT% over 85% with at least 15 FTA's with any team. |
| Inside Domination (20 GP) | Score at least 60 points in the paint with any team. |
| Kevin Garnett (25 GP) | Record at least 20 points, 13 rebounds and 5 assists with Kevin Garnett. |
| Kobe Bryant (25 GP) | Record at least 40 points, 5 rebounds and 5 assists with Kobe Bryant. |
| Lakers vs. Clippers (15 GP) | User controlled team must win this matchup on All-Star difficulty. |
| LeBron James (25 GP) | Record at least 35 points, 9 rebounds and 9 assists with LeBron James. |
| Lights Out (15 GP) | FG% over 55% for the game [minimum 40 FGA's] with any team. |
| Lockdown (20 GP) | Record at least 10 blocks and 10 steals with any team. |
| Online Ranked Game (15 GP) | Win one online ranked game. |
| Rebound Margin +7 (20 GP) | Win the rebound battle by a margin of +7 with any team. |
| Reel Critic (10 GP) | Download a reel from ReelViewer and rate it. |
| Second Unit (15 GP) | Score at least 40 bench points with any team. |
| Sprite Slam Dunk (35 GP) | Win the Sprite Slam Dunk Contest using LeBron James. |
| Spurs vs. Suns (15 GP) | User controlled team must win this matchup on All-Star difficulty. |
| Steve Nash (25 GP) | Record at least 20 points and 15 assists with Steve Nash. |
| Suns vs. Mavericks (15 GP) | User controlled team must win this matchup on All-Star difficulty. |
| Team 2K (20 GP) | Beat a Team 2K member in an online game. |
| Track Meet (15 GP) | Score at least 15 fastbreak points with any team. |
| Trivia (35 GP) | Answer 15 trivia questions correctly. |
| Yao Ming (25 GP) | Record at least 30 points, 12 rebounds and 4 blocks with Yao Ming. |
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